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Prognostic value of serum CD44, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels in patients with indolent non-Hodgkin lymphomas.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2012 Jan; Vol. 53 (1), pp. 50-6. Date of Electronic Publication: 2011 Oct 24. - Publication Year :
- 2012
-
Abstract
- Elevated serum CD44, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been linked to poor prognosis in aggressive lymphomas, but their utility in low grade lymphomas remains undefined. We evaluated serum CD44, VCAM-1 and ICAM-1 levels in 100 patients with newly diagnosed indolent NHL. The median pre-treatment values of the markers were as follows: CD44 540 ng/mL (range 156-1201), ICAM-1 311 ng/mL (range 102-1222) and VCAM-1 1165 ng/mL (range 248-4779). On univariate analysis, elevated sCD44, sICAM-1 and sVCAM-1 were significantly associated with worse overall (OS) and progression-free survival (PFS). In a subset analysis of patients with stage IV disease, the effects of sCD44 and sICAM-1 on OS persisted (p<0.05), as did the effect of sCD44 on PFS (p<0.01). In a multivariate analysis that included conventional prognostic factors and the Follicular Lymphoma International Prognostic Index (FLIPI) model, sICAM-1 demonstrated prognostic value for OS and PFS. We conclude that serum CD44, ICAM-1 and VCAM-1 can potentially be prognostic in patients with indolent NHL. Though the FLIPI model remains the gold standard for prognosis, these quantitative serologic markers may be useful as adjunct tools in assessing disease risk.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor blood
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Lymphoma, Non-Hodgkin pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Hyaluronan Receptors blood
Intercellular Adhesion Molecule-1 blood
Lymphoma, Non-Hodgkin blood
Vascular Cell Adhesion Molecule-1 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 21895545
- Full Text :
- https://doi.org/10.3109/10428194.2011.616611