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A phase III trial on the therapy of advanced pancreatic carcinoma. Evaluations of the Mallinson regimen and combined 5-fluorouracil, doxorubicin, and cisplatin.
- Source :
-
Cancer [Cancer] 1990 May 15; Vol. 65 (10), pp. 2207-12. - Publication Year :
- 1990
-
Abstract
- One hundred eighty-seven patients with histologically proven advanced pancreatic adenocarcinoma were randomly assigned to therapy with 5-fluorouracil (5-FU) alone, to the Mallinson regimen (combined and sequential 5-FU, cyclophosphamide, methotrexate, vincristine, and mitomycin C), or to combined 5-FU, doxorubicin, and cisplatin (FAP). Patients with both measurable and nonmeasurable disease were included and the primary study end point was survival. Among 41 patients with measurable disease, objective response rates were 7% for 5-FU alone, 21% for the Mallinson regimen, and 15% for FAP. The median interval to progression for each of the three regimens was 2.5 months. Survival curves intertwined with the median survival times for 5-FU alone and the Mallinson regimen at 4.5 months and for FAP at 3.5 months. Compared with 5-FU alone, both the Mallinson regimen and FAP produced significantly more toxicity. Neither the Mallinson regimen nor FAP can be recommended as therapy for advanced pancreatic carcinoma. Any chemotherapy for this disease should remain an experimental endeavor.
- Subjects :
- Adenocarcinoma mortality
Adult
Aged
Aged, 80 and over
Alopecia chemically induced
Antineoplastic Combined Chemotherapy Protocols adverse effects
Cisplatin administration & dosage
Cyclophosphamide administration & dosage
Doxorubicin administration & dosage
Female
Fluorouracil administration & dosage
Fluorouracil therapeutic use
Humans
Leukopenia chemically induced
Male
Methotrexate administration & dosage
Middle Aged
Mitomycin
Mitomycins administration & dosage
Pancreatic Neoplasms mortality
Randomized Controlled Trials as Topic
Remission Induction
Survival Rate
Thrombocytopenia chemically induced
Vincristine administration & dosage
Adenocarcinoma drug therapy
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Pancreatic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 65
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 2189551
- Full Text :
- https://doi.org/10.1002/1097-0142(19900515)65:10<2207::aid-cncr2820651007>3.0.co;2-y