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Palladium-catalyzed regio- and enantioselective fluorination of acyclic allylic halides.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2011 Oct 12; Vol. 133 (40), pp. 15902-5. Date of Electronic Publication: 2011 Sep 19. - Publication Year :
- 2011
-
Abstract
- This report describes the Pd(0)-catalyzed fluorination of linear allylic chlorides and bromides, yielding branched allylic fluorides in high selectivity. Many of the significant synthetic limitations previously associated with the preparation of these products are overcome by this catalytic method. We also demonstrate that a chiral bisphosphine-ligated palladium catalyst enables highly enantioselective access to a class of branched allylic fluorides that can be readily diversified to valuable fluorinated products.
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 133
- Issue :
- 40
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 21894884
- Full Text :
- https://doi.org/10.1021/ja206960k