Defining fetal growth restriction in mice: A standardized and clinically relevant approach.

Authors :: Dilworth MR
Kusinski LC
Baker BC
Renshall LJ
Greenwood SL
Sibley CP
Wareing M
Source :: Placenta [Placenta] 2011 Nov; Vol. 32 (11), pp. 914-6. Date of Electronic Publication: 2011 Sep 01.
Publication Year :: 2011
Abstract: The increasing number of mouse models of fetal growth restriction (FGR) make it crucial to standardize the way FGR is defined. By constructing growth curves in the placental-specific Igf2 knockout mouse (P0) it was demonstrated that 93% of P0 fetuses fell below the 5th centile of wild-type weights at E18.5, up from 44% at E16.5. This analysis, coupled with anthropomorphic measurements showing evidence of head sparing in P0 fetuses, allows clinical comparisons of FGR in mice through the use of clinically relevant growth curves. We suggest this as a standardized approach to defining FGR in mouse, and other animal models.<br /> (Copyright Â© 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Diagnostic Techniques, Obstetrical and Gynecological veterinary
Female
Fetal Growth Retardation classification
Fetal Growth Retardation veterinary
Fetal Weight physiology
Gestational Age
Growth Charts
Male
Mice, Inbred C57BL
Pregnancy
Prenatal Diagnosis methods
Prenatal Diagnosis standards
Prenatal Diagnosis veterinary
Reference Standards
Diagnostic Techniques, Obstetrical and Gynecological standards
Disease Models, Animal
Fetal Growth Retardation diagnosis
Mice

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