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Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis.
- Source :
-
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2011 Nov; Vol. 11 (11), pp. 2517-22. Date of Electronic Publication: 2011 Aug 22. - Publication Year :
- 2011
-
Abstract
- Primary graft dysfunction (PGD) after lung transplantation may result from ischemia reperfusion injury (IRI). The innate immune response to IRI may be mediated by Toll-like receptor and IL-1-induced long pentraxin-3 (PTX3) release. We hypothesized that elevated PTX3 levels were associated with PGD. We performed a nested case control study of lung transplant recipients with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) from the Lung Transplant Outcomes Group cohort. PTX3 levels were measured pretransplant, and 6 and 24 h postreperfusion. Cases were subjects with grade 3 PGD within 72 h of transplantation and controls were those without grade 3 PGD. Generalized estimating equations and multivariable logistic regression were used for analysis. We selected 40 PGD cases and 79 non-PGD controls. Plasma PTX3 level was associated with PGD in IPF but not COPD recipients (p for interaction < 0.03). Among patients with IPF, PTX3 levels at 6 and 24 h were associated with PGD (OR = 1.6, p = 0.02 at 6 h; OR = 1.4, p = 0.008 at 24 h). Elevated PTX3 levels were associated with the development of PGD after lung transplantation in IPF patients. Future studies evaluating the role of innate immune activation in IPF and PGD are warranted.<br /> (©2011 The Authors Journal compilation © 2011 The American Society of Transplantation and the American Society of Transplant Surgeons.)
- Subjects :
- Adult
Case-Control Studies
Female
Humans
Idiopathic Pulmonary Fibrosis physiopathology
Immunity, Innate
Lung Transplantation adverse effects
Male
Middle Aged
Primary Graft Dysfunction blood
Pulmonary Disease, Chronic Obstructive physiopathology
Pulmonary Disease, Chronic Obstructive surgery
Reperfusion Injury immunology
C-Reactive Protein metabolism
Idiopathic Pulmonary Fibrosis surgery
Lung Transplantation physiology
Primary Graft Dysfunction etiology
Reperfusion Injury complications
Serum Amyloid P-Component metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1600-6143
- Volume :
- 11
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 21883907
- Full Text :
- https://doi.org/10.1111/j.1600-6143.2011.03702.x