Reverse phase protein microarrays quantify and validate the bioenergetic signature as biomarker in colorectal cancer.

Authors :: Aldea M
Clofent J
Núñez de Arenas C
Chamorro M
Velasco M
Berrendero JR
Navarro C
Cuezva JM
Source :: Cancer letters [Cancer Lett] 2011 Dec 08; Vol. 311 (2), pp. 210-8. Date of Electronic Publication: 2011 Aug 06.
Publication Year :: 2011
Abstract: A reverse phase protein microarray approach has been applied to quantify proteins of energy metabolism in normal and tumor biopsies of colorectal cancer (CRC) patients. The metabolic proteome of CRC specimens revealed a profound shift towards and enhanced glycolytic phenotype and concurrent mitochondrial alteration. The metabolic signature discriminated CRC patients with highly significant differences in overall and disease-free prognosis. The quantification of the bioenergetic signature of the tumor offers a relevant biomarker of CRC that could contribute in the handling of these patients.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Adenocarcinoma mortality
Adenocarcinoma pathology
Aged
Biomarkers, Tumor metabolism
Colorectal Neoplasms mortality
Colorectal Neoplasms pathology
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
Adenocarcinoma metabolism
Biomarkers, Tumor analysis
Colorectal Neoplasms metabolism
Energy Metabolism physiology
Protein Array Analysis methods

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