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Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1990 May 15; Vol. 27 (10), pp. 1133-42. - Publication Year :
- 1990
-
Abstract
- The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/microtubular stabilization, and regional perfusion rates. The following is a report of a randomized, double-blind, placebo-controlled, multicenter study of 227 AD patients treated with nimodipine, a 1.4 dihydropyridine derivative and calcium channel antagonist. The subgroup receiving active drug (30 mg t.i.d.) experienced a prophylactic benefit across eight measures over 12 treatment weeks when contrasted with the disease progression seen among placebo recipients. Calcium channel blockers as neurotransmitter modulators and/or via calcium's theoretical role in neurofibrillary tangles, proteolysis, or neurofilament formation may represent a therapeutic opportunity for the AD patient.
- Subjects :
- Administration, Oral
Aged
Alzheimer Disease psychology
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Humans
Male
Multicenter Studies as Topic
Neuropsychological Tests
Randomized Controlled Trials as Topic
Alzheimer Disease drug therapy
Nimodipine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 27
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 2187540
- Full Text :
- https://doi.org/10.1016/0006-3223(90)90050-c