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Evidence of association between methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a candidate-gene association study in a South-eastern European population.

Authors :
Papandreou CN
Doxani C
Zdoukopoulos N
Vlachostergios PJ
Hatzidaki E
Bakalos G
Ziogas DC
Koufakis T
Zintzaras E
Source :
DNA and cell biology [DNA Cell Biol] 2012 Feb; Vol. 31 (2), pp. 193-8. Date of Electronic Publication: 2011 Aug 29.
Publication Year :
2012

Abstract

The methylenetetrahydrofolate reductase (MTHFR) gene has been proposed as a candidate gene for breast cancer (BC). However, the specific role of MTHFR polymorphisms and haplotypes has not been fully clarified and replicated. We examined the association of two common MTHFR polymorphisms (C677T and A1298C) and their haplotypes in a candidate-gene association study, involving 300 female patients with BC and 283 healthy women. The single locus analysis for the two polymorphisms revealed an association only for the C677T polymorphism [odds ratio (95% confidence interval), OR=2.05 (1.21-3.48)], but adjustment for age diminished this association [OR=1.76 (0.92-3.42)]. The menopausal status showed no significant effect in the association between the MTHFR polymorphisms and BC. The analysis of haplotypes showed an association for the C677-A1298 haplotypes (p=0.04). The available evidence from our study may support a contributory role of MTHFR polymorphisms in BC development. Future larger studies may help in elucidating the genetics of BC further.

Details

Language :
English
ISSN :
1557-7430
Volume :
31
Issue :
2
Database :
MEDLINE
Journal :
DNA and cell biology
Publication Type :
Academic Journal
Accession number :
21875371
Full Text :
https://doi.org/10.1089/dna.2011.1292