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Emergence and clonal dissemination of carbapenem-hydrolysing OXA-58-producing Acinetobacter baumannii isolates in Bolivia.
- Source :
-
Journal of medical microbiology [J Med Microbiol] 2012 Jan; Vol. 61 (Pt 1), pp. 80-84. Date of Electronic Publication: 2011 Aug 26. - Publication Year :
- 2012
-
Abstract
- Acinetobacter baumannii is an emerging multidrug-resistant pathogen and very little information is available regarding its imipenem resistance in Latin American countries such as Bolivia. This study investigated the antimicrobial resistance profile of 46 clinical strains from different hospitals in Cochabamba, Bolivia, from March 2008 to July 2009, and the presence of carbapenemases as a mechanism of resistance to imipenem. Isolates were obtained from 46 patients (one isolate per patient; 30 males,16 females) with an age range of 1 day to 84 years, and were collected from different sample types, the majority from respiratory tract infections (17) and wounds (13). Resistance to imipenem was detected in 15 isolates collected from different hospitals of the city. These isolates grouped into the same genotype, named A, and were resistant to all antibiotics tested including imipenem, with susceptibility only to colistin. Experiments to detect carbapenemases revealed the presence of the OXA-58 carbapenemase. Further analysis revealed the location of the bla(OXA-58) gene on a 40 kb plasmid. To our knowledge, this is the first report of carbapenem resistance in A. baumannii isolates from Bolivia that is conferred by the OXA-58 carbapenemase. The presence of this gene in a multidrug-resistant clone and its location within a plasmid is of great concern with regard to the spread of carbapenem-resistant A. baumannii in the hospital environment in Bolivia.
- Subjects :
- Acinetobacter Infections microbiology
Acinetobacter baumannii enzymology
Acinetobacter baumannii genetics
Adolescent
Aged
Aged, 80 and over
Anti-Bacterial Agents pharmacology
Bolivia epidemiology
Carbapenems pharmacology
Child
Child, Preschool
Cross Infection epidemiology
Cross Infection microbiology
Female
Humans
Imipenem metabolism
Imipenem pharmacology
Infant
Infant, Newborn
Male
Microbial Sensitivity Tests
Middle Aged
Plasmids genetics
Young Adult
beta-Lactamases genetics
Acinetobacter Infections epidemiology
Acinetobacter baumannii drug effects
Anti-Bacterial Agents metabolism
Carbapenems metabolism
Drug Resistance, Multiple, Bacterial genetics
Hospitals statistics & numerical data
beta-Lactamases biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5644
- Volume :
- 61
- Issue :
- Pt 1
- Database :
- MEDLINE
- Journal :
- Journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 21873380
- Full Text :
- https://doi.org/10.1099/jmm.0.032722-0