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Interstitial lung disease and ANCA-associated vasculitis: a retrospective observational cohort study.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2011 Nov; Vol. 50 (11), pp. 2035-43. Date of Electronic Publication: 2011 Aug 25. - Publication Year :
- 2011
-
Abstract
- Objectives: ANCA-associated vasculitis and interstitial lung disease (ILD) are uncommon conditions. The occurrence of both diseases in the same patient is increasingly recognized. Our aim was to ascertain the characteristics and outcomes of patients with ILD and ANCA-associated vasculitis.<br />Methods: A retrospective observational cohort study was performed. Patients who presented to the Hammersmith Hospital, London, with ANCA-associated vasculitis [granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis (MPA) or Churg-Strauss syndrome] who also had ILD were included. Following hospital discharge, all patients were followed up in a multi-disciplinary vasculitis clinic. We recorded patient demographics, diagnostic tests, treatment, complications and mortality.<br />Results: ILD was observed in 2.7% (n = 14) of our patients with ANCA-associated vasculitis (n = 510); all had MPO-ANCA and a clinical diagnosis of MPA, giving a prevalence of 7.2% in patients with MPA (n = 194). There was no significant difference in survival between patients with MPA and ILD and those with MPA alone.<br />Conclusion: It is important that physicians are aware of this clinical association and the presence of ILD should be considered in all patients with ANCA-associated vasculitis, especially those with MPO-ANCA. The possibility that patients with ILD may subsequently develop features of systemic vasculitis should also be remembered.
- Subjects :
- Aged
Aged, 80 and over
Cause of Death
Churg-Strauss Syndrome diagnosis
Churg-Strauss Syndrome therapy
Comorbidity
Female
Granulomatosis with Polyangiitis diagnosis
Granulomatosis with Polyangiitis therapy
Humans
Lung Diseases, Interstitial diagnosis
Lung Diseases, Interstitial therapy
Male
Microscopic Polyangiitis diagnosis
Microscopic Polyangiitis therapy
Middle Aged
Respiratory Function Tests
Retrospective Studies
Survival Rate
United Kingdom epidemiology
Churg-Strauss Syndrome epidemiology
Granulomatosis with Polyangiitis epidemiology
Lung Diseases, Interstitial epidemiology
Microscopic Polyangiitis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 50
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21873269
- Full Text :
- https://doi.org/10.1093/rheumatology/ker236