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Mother and daughter carrying the same KCNJ11 mutation but with a different response to switching from insulin to sulfonylurea.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2011 Nov; Vol. 94 (2), pp. e50-2. Date of Electronic Publication: 2011 Aug 25. - Publication Year :
- 2011
-
Abstract
- KCNJ11 gene mutations are related to permanent neonatal diabetes mellitus (PNDM). Glycemic stability minimizes the risk of complications. Sulfonylureas (SU) are the proven best therapeutic option. We report a 18-month follow-up of switching from insulin to SU in a mother and her daughter with PNDM due to KCNJ11 mutation.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Biomarkers blood
Blood Glucose drug effects
Blood Glucose metabolism
Child
DNA Mutational Analysis
Diabetes Mellitus blood
Drug Substitution
Female
Genetic Predisposition to Disease
Glycated Hemoglobin metabolism
Heredity
Humans
Pedigree
Phenotype
Time Factors
Treatment Outcome
Diabetes Mellitus drug therapy
Diabetes Mellitus genetics
Hypoglycemic Agents administration & dosage
Insulin administration & dosage
Mothers
Mutation
Nuclear Family
Potassium Channels, Inwardly Rectifying genetics
Sulfonylurea Compounds administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8227
- Volume :
- 94
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 21871684
- Full Text :
- https://doi.org/10.1016/j.diabres.2011.07.039