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Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain.
- Source :
-
Neuroscience letters [Neurosci Lett] 2011 Oct 03; Vol. 503 (2), pp. 110-4. Date of Electronic Publication: 2011 Aug 17. - Publication Year :
- 2011
-
Abstract
- Stachybotrys microspora triprenyl phenol-7 (SMTP-7) is a novel fibrinolytic agent with anti-inflammatory effect. Previous study demonstrated that SMTP-7 further ameliorated infarction volume in a mouse embolic stroke model compared with tissue type plasminogen activator (tPA), but the reason SMTP-7 has more beneficial effect than tPA has not yet been determined. In the present study, we investigated whether SMTP-7 has an intrinsic neuroprotective effect against transient focal cerebral ischemia (tFCI). Sprague-Dawley rats were subjected to tFCI by intraluminal middle cerebral artery occlusion for 2h. Following induction of tFCI, rats were randomized into two groups based on the agent administered: SMTP-7 group and vehicle group. We examined cerebral infarction volume 24h after reperfusion, and evaluated superoxide production, the expressions of nitrotyrosine and matrix metalloproteinase-9 (MMP-9), which play major roles in secondary brain injury and hemorrhagic transformation. The findings showed that SMTP-7 significantly suppressed superoxide production, the expression of nitrotyrosine and MMP-9 after tFCI, and consequently attenuated ischemic neuronal damage. These results suggest that SMTP-7 has an intrinsic neuroprotective effect on ischemia/reperfusion injury through the suppression of oxidative stress and MMP-9 activation.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Blotting, Western
Ischemic Attack, Transient drug therapy
Ischemic Attack, Transient enzymology
Male
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species metabolism
Tyrosine analogs & derivatives
Tyrosine metabolism
Benzopyrans pharmacology
Brain Injuries drug therapy
Brain Injuries enzymology
Fibrinolytic Agents pharmacology
Matrix Metalloproteinase 9 biosynthesis
Pyrrolidinones pharmacology
Reperfusion Injury drug therapy
Reperfusion Injury enzymology
Stachybotrys chemistry
Superoxides metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 503
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 21871536
- Full Text :
- https://doi.org/10.1016/j.neulet.2011.08.018