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Anti-depressant-like activity of a novel serotonin type-3 (5-HT3) receptor antagonist in rodent models of depression.
- Source :
-
Indian journal of experimental biology [Indian J Exp Biol] 2011 Aug; Vol. 49 (8), pp. 619-26. - Publication Year :
- 2011
-
Abstract
- N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT3 antagonist identified from a series of compounds with higher pA2 (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depressants and confirmatory studies such as reversal of parthenolide induced depression and reserpine induced hypothermia. In FST (2 and 4 mg/kg) and TST (2 and 4 mg/kg), QCM-13 significantly reduced the duration of immobility in mice without affecting the base line locomotion. QCM-13 (2 and 4 mg/kg) was also found to have significant interaction with standard anti-depressants (fluoxetine and bupropion in FST and TST respectively). Further, reversal of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of QCM-13 for anti-depressant potential.
- Subjects :
- Animals
Antidepressive Agents administration & dosage
Antidepressive Agents pharmacology
Depression metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Hindlimb Suspension
Male
Mice
Molecular Structure
Motor Activity drug effects
Quinoxalines administration & dosage
Quinoxalines chemistry
Quinoxalines pharmacology
Rats
Rats, Wistar
Receptors, Serotonin, 5-HT3 metabolism
Serotonin 5-HT3 Receptor Antagonists administration & dosage
Serotonin 5-HT3 Receptor Antagonists chemistry
Serotonin 5-HT3 Receptor Antagonists pharmacology
Swimming
Antidepressive Agents therapeutic use
Depression drug therapy
Quinoxalines therapeutic use
Serotonin 5-HT3 Receptor Antagonists therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0019-5189
- Volume :
- 49
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Indian journal of experimental biology
- Publication Type :
- Academic Journal
- Accession number :
- 21870430