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In vitro and in vivo anticancer activity of (+)-spongistatin 1.
- Source :
-
Anticancer research [Anticancer Res] 2011 Sep; Vol. 31 (9), pp. 2773-9. - Publication Year :
- 2011
-
Abstract
- The marine natural product (+)-spongistatin 1 is an extremely potent growth inhibitory agent having activity against a wide variety of cancer cell lines, while exhibiting low cytotoxicity against quiescent human fibroblasts. Consistent with a microtubule-targeting mechanism of action, (+)-spongistatin 1 causes mitotic arrest in DU145 human prostate cancer cells. More importantly, (+)-spongistatin 1 exhibits significant in vivo antitumor activity in the LOX-IMVI human melanoma xenograft model. (+)-Spongistatin 1 is, thus, an important class of microtubule targeting anticancer agent that warrants further investigation.
- Subjects :
- ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism
Animals
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
In Vitro Techniques
Macrolides chemistry
Macrolides metabolism
Mice
Microscopy, Fluorescence
Stereoisomerism
Tubulin Modulators chemistry
Tubulin Modulators metabolism
Macrolides pharmacology
Tubulin Modulators pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 31
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 21868519