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Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential.
- Source :
-
Journal of natural products [J Nat Prod] 2011 Sep 23; Vol. 74 (9), pp. 1862-7. Date of Electronic Publication: 2011 Aug 25. - Publication Year :
- 2011
-
Abstract
- Isoliquiritigenin (1) and liquiritigenin (2) are structurally related flavonoids found in a variety of plants. The purpose of this study was to perform a comparative analysis of biological properties of these compounds in regard to their therapeutic potential for oral infections. Compound 1 demonstrated significant antibacterial activity against three major periodontopathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia. In contrast, 2 exerted less pronounced effects on the above bacterial species. Neither compound was effective against cariogenic bacteria (Streptococcus mutans and Streptococcus sobrinus). Furthermore, 1 exhibited a stronger inhibitory activity than 2 toward P. gingivalis collagenase and human matrix metalloproteinase 9. Finally, the capacity of 1 to attenuate the inflammatory response of macrophages induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS) was much higher when compared to 2. The activation of transcriptional factors nuclear factor-κB (NF-κB) p65 and activator protein-1 (AP-1) associated with the LPS-induced inflammatory response in macrophages was inhibited strongly by 1, but less affected by 2.
- Subjects :
- Chalcones
Drugs, Chinese Herbal chemistry
Flavanones chemistry
Fusobacterium nucleatum drug effects
Humans
Lipopolysaccharides pharmacology
Macrophages drug effects
Matrix Metalloproteinase Inhibitors
Molecular Structure
NF-kappa B drug effects
Nuclear Magnetic Resonance, Biomolecular
Porphyromonas gingivalis drug effects
Transcription Factor AP-1 drug effects
Transcription Factor RelA
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Drugs, Chinese Herbal isolation & purification
Drugs, Chinese Herbal pharmacology
Flavanones isolation & purification
Flavanones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 74
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 21866899
- Full Text :
- https://doi.org/10.1021/np200174h