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Identification and phenotypic characterization of γδ T cells in rat lymph.
- Source :
-
Research in veterinary science [Res Vet Sci] 2012 Aug; Vol. 93 (1), pp. 168-71. Date of Electronic Publication: 2011 Aug 20. - Publication Year :
- 2012
-
Abstract
- γδ T cells represent an unconventional subset of T lymphocytes that are abundant in epithelial tissues and serve as an early immune defense against microbes. We have, for the first time, identified γδ T cells in steady-state thoracic duct lymph (TDL) from rats. The lymph contains γδ T cells expressing CD8 but not CD4, CD25, MHC-II or CD103. The percentage of TDL γδ T cells in rats does not change when the mesenteric lymph nodes (MLN) are surgically removed. Our data suggest that a proportion of γδ T cells migrate from the intestine into rat TDL, under steady-state conditions.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1532-2661
- Volume :
- 93
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Research in veterinary science
- Publication Type :
- Academic Journal
- Accession number :
- 21862089
- Full Text :
- https://doi.org/10.1016/j.rvsc.2011.07.014