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Genetic features of blaNDM-1-positive Enterobacteriaceae.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2011 Nov; Vol. 55 (11), pp. 5403-7. Date of Electronic Publication: 2011 Aug 22. - Publication Year :
- 2011
-
Abstract
- Genetic features associated with the bla(NDM-1) gene were investigated in 6 Escherichia coli, 7 Klebsiella pneumoniae, 1 Citrobacter freundii, 1 Proteus mirabilis, and 1 Providencia stuartii isolate of worldwide origin. Clonal diversity was observed for both E. coli and K. pneumoniae. The bla(NDM-1) gene was carried by different plasmid types (IncA/C, IncF, IncL/M, or untypeable) and was likely chromosome borne in two isolates. The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes.
- Subjects :
- Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Citrobacter freundii drug effects
Citrobacter freundii enzymology
Citrobacter freundii genetics
Drug Resistance, Bacterial genetics
Enterobacteriaceae drug effects
Escherichia coli drug effects
Escherichia coli enzymology
Escherichia coli genetics
Klebsiella pneumoniae drug effects
Klebsiella pneumoniae enzymology
Klebsiella pneumoniae genetics
Methyltransferases genetics
Microbial Sensitivity Tests
Plasmids genetics
Proteus mirabilis drug effects
Proteus mirabilis enzymology
Proteus mirabilis genetics
Enterobacteriaceae enzymology
Enterobacteriaceae genetics
beta-Lactamases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 55
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 21859933
- Full Text :
- https://doi.org/10.1128/AAC.00585-11