Back to Search
Start Over
Prevalence of etravirine-associated mutations in clinical samples with genotypic resistance to nevirapine and efavirenz in Brazilian clinics.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2011 Aug; Vol. 57 Suppl 3, pp. S193-6. - Publication Year :
- 2011
-
Abstract
- Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy.
- Subjects :
- Alkynes
Antiretroviral Therapy, Highly Active methods
Brazil
Cyclopropanes
HIV genetics
HIV isolation & purification
HIV Infections drug therapy
Humans
Mutation, Missense
Nitriles
Prevalence
Pyrimidines
Anti-HIV Agents pharmacology
Benzoxazines pharmacology
Drug Resistance, Viral
HIV drug effects
HIV Infections virology
Nevirapine pharmacology
Pyridazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-7884
- Volume :
- 57 Suppl 3
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 21857317
- Full Text :
- https://doi.org/10.1097/QAI.0b013e31821e9cf6