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Prenatal exposure to bisphenol A and phthalates and infant neurobehavior.
- Source :
-
Neurotoxicology and teratology [Neurotoxicol Teratol] 2011 Sep-Oct; Vol. 33 (5), pp. 558-66. Date of Electronic Publication: 2011 Aug 10. - Publication Year :
- 2011
-
Abstract
- Objective: To examine the association of prenatal exposure to bisphenol A and select common phthalates with infant neurobehavior measured at 5 weeks.<br />Methods: We compared the concentration of maternal urinary metabolites of bisphenol A and phthalates at two distinct time points in pregnancy (16w, 26w) with scores on the NICU Network Neurobehavioral Scale (NNNS) at 5 weeks of age in a cohort of 350 mother/infant pairs.<br />Results: Prenatal exposure to BPA was not significantly associated with neurobehavioral outcomes at 5 weeks. Significant associations between prenatal exposure to measured phthalates and infant neurobehavioral outcomes differed by type of phthalate and were only seen with exposure measured at 26 weeks. Higher total di-butyl phthalate (DBP) metabolites at 26w were associated with improved behavioral organization evidenced by decreased arousal (p=.04), increased self-regulation (p=.052), and decreased handling (p=.02). In males, higher total di-2-ethylhexyl phthalate (DEHP) metabolites at 26w were associated with more nonoptimal reflexes (p=.02).<br />Conclusion: The association between prenatal phthalate exposure and infant neurobehavior differed by type of phthalate and was evident only with exposure measured at 26w. Prenatal exposure to DBP was associated with improved behavioral organization in 5-week-old infants. Prenatal exposure to DEHP was associated with nonoptimal reflexes in male infants. There was no evidence of an association between prenatal BPA exposure and infant neurobehavior.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Benzhydryl Compounds
Dibutyl Phthalate toxicity
Dibutyl Phthalate urine
Diethylhexyl Phthalate toxicity
Diethylhexyl Phthalate urine
Environmental Pollutants pharmacokinetics
Environmental Pollutants urine
Female
Humans
Infant
Male
Neuropsychological Tests statistics & numerical data
Phenols urine
Phthalic Acids pharmacokinetics
Phthalic Acids urine
Pregnancy
Prenatal Exposure Delayed Effects urine
Time Factors
Environmental Pollutants toxicity
Neurotoxicity Syndromes diagnosis
Phenols toxicity
Phthalic Acids toxicity
Prenatal Exposure Delayed Effects psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9738
- Volume :
- 33
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurotoxicology and teratology
- Publication Type :
- Academic Journal
- Accession number :
- 21854843
- Full Text :
- https://doi.org/10.1016/j.ntt.2011.08.003