Back to Search
Start Over
Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.
- Source :
-
PloS one [PLoS One] 2011; Vol. 6 (8), pp. e23371. Date of Electronic Publication: 2011 Aug 10. - Publication Year :
- 2011
-
Abstract
- Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wide association scan (GWAS) of knee OA in Japanese populations. The frequencies for rs10947262 were compared in 36,408 controls and 5,749 knee OA cases from European-descent populations. rs7775228 was tested in 32,823 controls and 1,837 knee OA cases of European descent. The risk (major) allele at rs10947262 in Caucasian samples was not significantly associated with an odds ratio (OR) = 1.07 (95%CI 0.94 -1.21; p = 0.28). For rs7775228 the meta-analysis resulted in OR = 0.94 (95%CI 0.81-1.09; p = 0.42) for the allele associated with risk in the Japanese GWAS. In Japanese individuals these two SNPs are in strong linkage disequilibrium (LD) (r(2) = 0.86) with the HLA class II haplotype DRB1*1502 DQA1*0103 DQB1*0601 (frequency 8%). In Caucasian and Chinese samples, using imputed data, these SNPs appear not to be in LD with that haplotype (r(2)<0.07). The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals.
- Subjects :
- Aged
Butyrophilins
Case-Control Studies
Female
Genetic Loci genetics
Genetic Markers
Genetics, Population
Humans
Linkage Disequilibrium genetics
Male
Meta-Analysis as Topic
Middle Aged
Reproducibility of Results
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-D Antigens genetics
Membrane Glycoproteins genetics
Osteoarthritis, Knee genetics
Polymorphism, Single Nucleotide genetics
White People genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 6
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 21853121
- Full Text :
- https://doi.org/10.1371/journal.pone.0023371