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EGFR gene copy number alteration is a better prognostic indicator than protein overexpression in oral tongue squamous cell carcinomas.
- Source :
-
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2011 Oct; Vol. 47 (15), pp. 2364-72. Date of Electronic Publication: 2011 Aug 16. - Publication Year :
- 2011
-
Abstract
- Although epidermal growth factor receptor (EGFR) is particularly important in the pathogenesis of head and neck squamous cell carcinomas (HNSCCs), conflicting data have been reported on the correlation between EGFR copy number and survival and the association between EGFR copy number and protein expression. Anatomical site of the tumour in HNSCCs may likely contribute to the discordance of the above points as EGFR expression may differ between the sub-sites of HNSCCs. Thus, in this study, we focused on oral tongue squamous cell carcinomas (OTSCCs). To investigate the association between EGFR copy number alteration and overexpression and to determine which is the more reliable prognostic indicator, Fluorescence in situ hybridisation (FISH) and immunohistochemical staining (IHC) were performed at a single institution on samples from 89 patients with OTSCCs undergoing surgery as the primary treatment modality. Thirty-two (36%) of 89 cases demonstrated an EGFR copy number alteration. EGFR protein expression was found in all 89 cases, of which 82.0% showed overexpression. No significant correlation was found between gene copy number and protein overexpression. Gene copy number alteration was significantly associated with reduced disease-free survival (P=0.048) and overall survival (P=0.001). Multivariate Cox proportional hazards analysis demonstrated that EGFR copy number increase was significantly correlated with overall survival (P=0.001). EGFR copy number status is a more reliable indicator than protein overexpression of the survival rate in OTSCCs. FISH analysis of the EGFR status is useful in predicting poor prognosis in OTSCCs.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Biomarkers, Tumor analysis
Biopsy
Carcinoma, Squamous Cell chemistry
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell surgery
Disease-Free Survival
ErbB Receptors analysis
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Japan
Kaplan-Meier Estimate
Male
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Risk Assessment
Risk Factors
Survival Rate
Time Factors
Tongue Neoplasms chemistry
Tongue Neoplasms mortality
Tongue Neoplasms pathology
Tongue Neoplasms surgery
Treatment Outcome
Biomarkers, Tumor genetics
Carcinoma, Squamous Cell genetics
ErbB Receptors genetics
Gene Dosage
Tongue Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0852
- Volume :
- 47
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Publication Type :
- Academic Journal
- Accession number :
- 21852109
- Full Text :
- https://doi.org/10.1016/j.ejca.2011.07.006