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Population genetic analyses of the AmpFlSTR® NGM™ in Brazil.

Authors :: Raimann PE
Hirschfeld-Campolongo G
Schumacher S
de Mattos Almeida SE
da Silva CM
Rodenbusch R
Bassini AS
de Souza LF
Nascimento EC
de Oliveira ES
Santos VR
de Oliveira EC
Auler-Bittencourt EA
da Rocha Hirschfeld-Campolongo RC
E Sousa ML
de Figueiredo HP
de Figueiredo BB
Silva R
Moura-Neto RS
Source :: International journal of legal medicine [Int J Legal Med] 2012 Mar; Vol. 126 (2), pp. 337-41. Date of Electronic Publication: 2011 Aug 18.
Publication Year :: 2012
Abstract: Population data of 15 short tandem repeat loci of the AmpFlSTR® next generation multiplex (NGM)™ were obtained from a sample of 835 individuals. The loci are the ten short tandem repeats (STRs) in the SGM Plus® Kit plus the EDNAP- and ENSFI-recommended STRs D10S1248, D22S1045, D2S441, D1S1656, and D12S391. Allele frequency and other forensically relevant statistics data were generated for the NGM loci into five current country macroregions of Brazil (North, Northeast, Central West, Southeast, and South). All the analyzed loci meet Hardy-Weinberg equilibrium expectations and no linkage disequilibrium in all pairs of loci. The observed and expected heterozygosity, power of discrimination, polymorphic information content, and the other population-genetic indices were calculated. The overall power of discrimination was greater than 0.99999999999999999996 and the combined power of exclusion was greater than 0.9999998 in all Brazilian populations. Comparative analysis between populations from different Brazilian macroregions as well as between Brazil and Caucasian, African Americans, and Hispanic US populations are presented.