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[Effect of vitamin C on the condition of NO-synthase system in experimental stomach ulcer].
- Source :
-
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2011; Vol. 57 (2), pp. 90-8. - Publication Year :
- 2011
-
Abstract
- We investigated the effect of Vitamin C (Vit C) on the changes of activity of the enzymes of NO-synthase system, nitric oxide content, lipoperoxidation processes, activity of SOD and catalase in gastric mucosa (GM), and concentrations of L-arginine, Vit C and Vit E in the blood of rats under conditions of experimental ulcer of the stomach caused by adrenaline injection. Vit C displayed a pronounced antioxidant action, reduced the degree of destructive affections, diminished the activity of iNOS and lipoperoxidation processes, decreased the NO content and SOD activity. Furthermore, the concentration of L-arginine and Vit C in the blood was increased. Combined action of Vit C with L-arginine reduced the degree of GM lesions, activity of eNOS and the content of NO in GM whereas the concentration of L-arginine in blood was increased. Under conditions of Vit C action and iNOS and COX-2 blockage, the activity of NO-synthases and lipoperoxidation processes were slightly decreased, indicating on dominant action of Vit C.
- Subjects :
- Animals
Antioxidants administration & dosage
Arginine blood
Ascorbic Acid administration & dosage
Disease Models, Animal
Gastric Mucosa enzymology
Gastric Mucosa metabolism
Lipid Peroxidation drug effects
Nitric Oxide metabolism
Rats
Stomach Ulcer blood
Stomach Ulcer enzymology
Superoxide Dismutase metabolism
Antioxidants therapeutic use
Ascorbic Acid therapeutic use
Gastric Mucosa drug effects
Nitric Oxide Synthase Type II metabolism
Stomach Ulcer drug therapy
Subjects
Details
- Language :
- Ukrainian
- ISSN :
- 2522-9028
- Volume :
- 57
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)
- Publication Type :
- Academic Journal
- Accession number :
- 21848229