Cyclooxygenase-2 immunoexpression in breast cancer: progesterone receptor influence.

Authors :: Almeida M
Muñoz J
Nunes S
Fonseca-Moutinho J
Source :: Cancer epidemiology [Cancer Epidemiol] 2011 Dec; Vol. 35 (6), pp. e81-4. Date of Electronic Publication: 2011 Aug 16.
Publication Year :: 2011
Abstract: Background: In breast cancer cyclooxygenase-2 overexpression is related with poor outcomes, but the clinical relevance of cyclooxygenase-2 is still unclear. Progesterone receptor is a regulator of cyclooxygenase-2 expression. We postulate that progesterone receptor was associated to cyclooxygenase-2 expression and clinicopathologic factors in breast cancer.<br />Methods: Cyclooxygenase-2 and progesterone receptor expression was analyzed, by immunohistochemistry, in 31 cases of invasive ductal carcinoma.<br />Results: The expression of cyclooxygenase-2 and progesterone receptor was observed in 64.5% and 45.2% of the tumors, respectively. We found 11 tumors with both cyclooxygenase-2 and progesterone receptor overexpression and they are related with tumor lower size and lower axillary node metastasis.<br />Conclusion: These results suggest that progesterone receptor has a protective role in breast cancer by inhibiting chronic inflammatory pathway.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Adult
Aged
Aged, 80 and over
Breast Neoplasms pathology
Carcinoma, Ductal, Breast pathology
Female
Humans
Immunohistochemistry
Lymphatic Metastasis pathology
Middle Aged
Neoplasm Grading
Neoplasm Staging
Prognosis
Breast Neoplasms metabolism
Carcinoma, Ductal, Breast metabolism
Cyclooxygenase 2 biosynthesis
Receptors, Progesterone biosynthesis

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