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Evaluation of gene expression in MG63 human osteoblastlike cells exposed to tantalum powder by microarray technology.
- Source :
-
The International journal of periodontics & restorative dentistry [Int J Periodontics Restorative Dent] 2011 Jul-Aug; Vol. 31 (4), pp. e17-28. - Publication Year :
- 2011
-
Abstract
- Conventional orthopedic implants are composed from titanium. To improve some characteristics (ie, volumetric porosity, modulus of elasticity, frictional modulus), a new porous tantalum biomaterial has been developed and its biocompatibility reported. By using DNA microarrays containing 20,000 genes, several genes whose expression were significantly up- or down-regulated were identified in an osteoblastlike cell line (MG63) cultured with tantalum powder (TP). The differentially expressed genes cover a broad range of functional activities: signaling transduction; transcription; cell cycle regulation, proliferation, and apoptosis; and cytoskeleton formation. To the authors' knowledge, the data reported represent the first genetic portrait of TP.
- Subjects :
- Apoptosis genetics
Biocompatible Materials chemistry
Cell Culture Techniques
Cell Cycle genetics
Cell Line
Cell Proliferation drug effects
Cytoskeleton genetics
Down-Regulation genetics
Elastic Modulus
Friction
Humans
Materials Testing
Porosity
Powders
Signal Transduction genetics
Tantalum chemistry
Transcription, Genetic genetics
Up-Regulation genetics
Biocompatible Materials pharmacology
Gene Expression Profiling methods
Oligonucleotide Array Sequence Analysis methods
Osteoblasts drug effects
Tantalum pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1945-3388
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The International journal of periodontics & restorative dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 21837296