Encapsulation of docetaxel into PEGylated gold nanoparticles for vectorization to cancer cells.

Authors :: François A
Laroche A
Pinaud N
Salmon L
Ruiz J
Robert J
Astruc D
Source :: ChemMedChem [ChemMedChem] 2011 Nov 04; Vol. 6 (11), pp. 2003-8. Date of Electronic Publication: 2011 Aug 10.
Publication Year :: 2011
Abstract: Encapsulation of docetaxel and its solubilization in water was carried out in PEGylated gold nanoparticles (AuNPs) as shown by 1H NMR (600 MHz) and UV/Vis spectroscopy and dynamic light scattering. Vectorization of PEGylated AuNP-encapsulated docetaxel was probed in vitro toward human colon carcinoma (HCT15) and human breast cancer (MCF7) cells. AuNPs alone presented no cytotoxicity toward either MCF7 or HCT15 adenocarcinoma cells. AuNP-docetaxel was found to be 2.5-fold more efficient than docetaxel alone against MCF7 cells, and the IC50 value of AuNP-docetaxel against HCT15 cells was lower than that of free docetaxel; the increased efficiency brought about by AuNP drug encapsulation was ∼1.5-fold.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Adenocarcinoma drug therapy
Breast Neoplasms drug therapy
Cell Line, Tumor
Colonic Neoplasms drug therapy
Docetaxel
Female
Humans
Magnetic Resonance Spectroscopy
Solubility
Spectrophotometry, Ultraviolet
Taxoids chemistry
Antineoplastic Agents administration & dosage
Antineoplastic Agents chemistry
Drug Carriers
Gold chemistry
Metal Nanoparticles administration & dosage
Metal Nanoparticles chemistry
Polyethylene Glycols chemistry
Taxoids administration & dosage

Full Text Access

Tools