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Staphylococcal α-toxin induces a higher T cell proliferation and interleukin-31 in atopic dermatitis.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 2011; Vol. 156 (4), pp. 412-5. Date of Electronic Publication: 2011 Aug 10. - Publication Year :
- 2011
-
Abstract
- Background: Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-producing Staphylococcus aureus which is in turn positively correlated with the severity of eczema.<br />Methods: IN this study we addressed T cell proliferation and T cell as well as monocyte cytokine secretion upon α-toxin stimulation in peripheral blood mononuclear cells (PBMCs) from AD patients compared to healthy controls.<br />Results: We found that α-toxin stimulation of PBMCs markedly enhanced T cell proliferation both in patients with AD and healthy controls and was significantly increased in AD patients compared to healthy controls. PBMCs of AD patients secreted significantly more IL-31 compared to those of healthy controls upon α-toxin and SEB stimulation. Moreover, α-toxin stimulation yielded an increase in T cell (IL-2, IL-9, IL-10 and IFN-γ) as well as monocyte (IL-1β and TNF-α) cytokine secretion.<br />Conclusion: Our results could partly explain how skin colonization and infection with S. aureus can contribute to chronic skin inflammation and pruritus in AD.<br /> (Copyright © 2011 S. Karger AG, Basel.)
- Subjects :
- Cells, Cultured
Cytokines metabolism
Humans
Leukocytes, Mononuclear drug effects
Leukocytes, Mononuclear immunology
Lymphocyte Activation drug effects
T-Lymphocytes, Helper-Inducer drug effects
Bacterial Toxins pharmacology
Dermatitis, Atopic immunology
Hemolysin Proteins pharmacology
Interleukins metabolism
Lymphocyte Activation immunology
T-Lymphocytes, Helper-Inducer immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0097
- Volume :
- 156
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21832830
- Full Text :
- https://doi.org/10.1159/000323905