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Manipulation and tracking of superparamagnetic nanoparticles using MRI.
- Source :
-
Nanotechnology [Nanotechnology] 2008 Oct 01; Vol. 19 (39), pp. 395102. Date of Electronic Publication: 2008 Aug 08. - Publication Year :
- 2008
-
Abstract
- The use of magnetic fields in magnetic resonance imaging (MRI) for the tracking and delivery of chemotherapeutics bound to superparamagnetic nanoparticles offers a promising method for the non-invasive treatment of inoperable tumours. Here we demonstrate that superparamagnetic magnetite nanoparticles fabricated by an easily scalable method can be driven and tracked in real time at high velocities in vitro using MRI hardware. Force balance calculations are consistent with the magnetic properties of individual 10 nm diameter particles that move collectively as micron sized agglomerates with hydrodynamic diameter similar to that inferred from zero-magnetic-field dynamic light scattering measurements.
Details
- Language :
- English
- ISSN :
- 0957-4484
- Volume :
- 19
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 21832584
- Full Text :
- https://doi.org/10.1088/0957-4484/19/39/395102