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Manipulation and tracking of superparamagnetic nanoparticles using MRI.

Authors :
Darton NJ
Sederman AJ
Ionescu A
Ducati C
Darton RC
Gladden LF
Slater NK
Source :
Nanotechnology [Nanotechnology] 2008 Oct 01; Vol. 19 (39), pp. 395102. Date of Electronic Publication: 2008 Aug 08.
Publication Year :
2008

Abstract

The use of magnetic fields in magnetic resonance imaging (MRI) for the tracking and delivery of chemotherapeutics bound to superparamagnetic nanoparticles offers a promising method for the non-invasive treatment of inoperable tumours. Here we demonstrate that superparamagnetic magnetite nanoparticles fabricated by an easily scalable method can be driven and tracked in real time at high velocities in vitro using MRI hardware. Force balance calculations are consistent with the magnetic properties of individual 10 nm diameter particles that move collectively as micron sized agglomerates with hydrodynamic diameter similar to that inferred from zero-magnetic-field dynamic light scattering measurements.

Details

Language :
English
ISSN :
0957-4484
Volume :
19
Issue :
39
Database :
MEDLINE
Journal :
Nanotechnology
Publication Type :
Academic Journal
Accession number :
21832584
Full Text :
https://doi.org/10.1088/0957-4484/19/39/395102