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Clinical impact of albuminuria in diabetic nephropathy.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2012 Feb; Vol. 16 (1), pp. 96-101. Date of Electronic Publication: 2011 Aug 10. - Publication Year :
- 2012
-
Abstract
- Patients suffering from diabetic nephropathy, resulting in end-stage renal failure, are increasing in number. The pathophysiology of diabetic nephropathy remains to be fully investigated. In the clinical setting, the presence of albuminuria/overt proteinuria and a low glomerular filtration rate may predict poor renal prognosis, but the prognosis of the normoalbuminuric renally insufficient diabetic patient remains controversial. In addition to the measurement of urinary albumin excretion, biomarker studies to detect diabetic nephropathy more specifically at the early stage have been performed worldwide. There is a growing body of evidence for remission and/or regression of diabetic nephropathy, which may be an indicator for cardiovascular and renal risk reduction. Deeper insights into the pathological characteristics as well as the clinical impact of albuminuria on renal and cardiovascular outcome are required.
- Subjects :
- Albuminuria epidemiology
Biomarkers
Cardiovascular Diseases etiology
Diabetes Mellitus, Type 2 epidemiology
Diabetic Nephropathies diagnosis
Glomerular Filtration Rate
Hematuria etiology
Humans
Japan epidemiology
Kidney physiopathology
Prognosis
Proteinuria physiopathology
Remission Induction
Albuminuria physiopathology
Diabetic Nephropathies physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 21830044
- Full Text :
- https://doi.org/10.1007/s10157-011-0508-z