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Biogenesis of spliceosomal small nuclear ribonucleoproteins.
- Source :
-
Wiley interdisciplinary reviews. RNA [Wiley Interdiscip Rev RNA] 2011 Sep-Oct; Vol. 2 (5), pp. 718-31. Date of Electronic Publication: 2011 Apr 25. - Publication Year :
- 2011
-
Abstract
- Virtually, all eukaryotic mRNAs are synthesized as precursor molecules that need to be extensively processed in order to serve as a blueprint for proteins. The three most prevalent processing steps are the capping reaction at the 5'-end, the removal of intervening sequences by splicing, and the formation of poly (A)-tails at the 3'-end of the message by polyadenylation. A large number of proteins and small nuclear ribonucleoprotein complexes (snRNPs) interact with the mRNA and enable the different maturation steps. This chapter focuses on the biogenesis of snRNPs, the major components of the pre-mRNA splicing machinery (spliceosome). A large body of evidence has revealed an intricate and segmented pathway for the formation of snRNPs that involves nucleo-cytoplasmic transport events and elaborates assembly strategies. We summarize the knowledge about the different steps with an emphasis on trans-acting factors of snRNP maturation of higher eukaryotes. WIREs RNA 2011 2 718-731 DOI: 10.1002/wrna.87 For further resources related to this article, please visit the WIREs website.<br /> (Copyright © 2011 John Wiley & Sons, Ltd.)
- Subjects :
- Active Transport, Cell Nucleus
Animals
Humans
Mice
Models, Biological
Muscular Atrophy, Spinal genetics
Muscular Atrophy, Spinal metabolism
RNA Polymerase II metabolism
RNA Precursors genetics
RNA Precursors metabolism
RNA Splicing
RNA, Small Nuclear genetics
RNA, Small Nuclear metabolism
Ribonucleoproteins, Small Nuclear genetics
Spliceosomes genetics
Survival of Motor Neuron 1 Protein genetics
Survival of Motor Neuron 1 Protein metabolism
Ribonucleoproteins, Small Nuclear biosynthesis
Spliceosomes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1757-7012
- Volume :
- 2
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Wiley interdisciplinary reviews. RNA
- Publication Type :
- Academic Journal
- Accession number :
- 21823231
- Full Text :
- https://doi.org/10.1002/wrna.87