Back to Search
Start Over
Interferon-lambda and therapy for chronic hepatitis C virus infection.
- Source :
-
Trends in immunology [Trends Immunol] 2011 Sep; Vol. 32 (9), pp. 443-50. Date of Electronic Publication: 2011 Aug 05. - Publication Year :
- 2011
-
Abstract
- Interferon (IFN)-α, a type-I IFN, is widely used to treat chronic hepatitis C virus infection, but the broad expression of IFN-α receptors often leads to adverse reactions in many organs. Here, we examine IFN-λ, a type-III IFN, as a therapeutic alternative to IFN-α. Like IFN-α, IFN-λ also induces antiviral activity in hepatocytes, but might induce fewer adverse reactions because its receptor is largely restricted to cells of epithelial origin. We also discuss the recent discovery of single nucleotide polymorphisms (SNPs) near the human IFN-λ3 gene, IL28B, that correlate strongly with the ability to achieve a sustained virological response to therapy with pegylated IFN-α plus ribavirin in patients with chronic hepatitis C.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Animals
Antiviral Agents administration & dosage
Antiviral Agents therapeutic use
Chromosomes, Human, Pair 19 chemistry
Chromosomes, Human, Pair 19 genetics
Chromosomes, Human, Pair 19 immunology
Drug Therapy, Combination
Gene Expression Regulation immunology
Hepacivirus immunology
Humans
Interferon alpha-2
Interferon-alpha administration & dosage
Interferon-alpha therapeutic use
Interferons
Interleukins chemistry
Interleukins genetics
Mice
Polyethylene Glycols administration & dosage
Polyethylene Glycols therapeutic use
Polymorphism, Single Nucleotide
Promoter Regions, Genetic immunology
Recombinant Proteins administration & dosage
Recombinant Proteins therapeutic use
Ribavirin administration & dosage
Ribavirin therapeutic use
Transcription Factors immunology
Transcription Factors metabolism
Treatment Outcome
Viral Load drug effects
Hepacivirus drug effects
Hepatitis C, Chronic genetics
Hepatitis C, Chronic immunology
Hepatitis C, Chronic therapy
Hepatitis C, Chronic virology
Immunotherapy methods
Interleukins immunology
Interleukins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21820962
- Full Text :
- https://doi.org/10.1016/j.it.2011.07.002