Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.

Authors :: Carneiro PF
Pinto Mdo C
Coelho TS
Cavalcanti BC
Pessoa C
de Simone CA
Nunes IK
de Oliveira NM
de Almeida RG
Pinto AV
de Moura KC
da Silva PA
da Silva Júnior EN
Source :: European journal of medicinal chemistry [Eur J Med Chem] 2011 Sep; Vol. 46 (9), pp. 4521-9. Date of Electronic Publication: 2011 Jul 23.
Publication Year :: 2011
Abstract: Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.<br /> (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)

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