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Laboratory evaluation of clopidogrel responsiveness by platelet function and genetic methods.
- Source :
-
American journal of hematology [Am J Hematol] 2011 Dec; Vol. 86 (12), pp. 1032-4. Date of Electronic Publication: 2011 Aug 02. - Publication Year :
- 2011
-
Abstract
- Clopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel-induced platelet inhibition and published literature correlates suboptimal clopidogrel response to adverse cardiovascular outcomes. Genetic polymorphisms are thought to affect conversion of the prodrug to the active metabolite, and the FDA has recently added a black-box warning to clopidogrel to highlight the effects of these polymorphisms on drug bioavailability and to inform prescribers about the availability of genetic testing. For these reasons, there is growing interest in the use of laboratory tests to monitor patients treated with clopidogrel. This article summarizes the currently available laboratory testing, including platelet function tests and genotyping for CYP2C19 variants.<br /> (Copyright © 2011 Wiley-Liss, Inc.)
- Subjects :
- Aryl Hydrocarbon Hydroxylases genetics
Aryl Hydrocarbon Hydroxylases metabolism
Biological Availability
Biotransformation
Clopidogrel
Cytochrome P-450 CYP2C19
Genotyping Techniques
Humans
Platelet Aggregation Inhibitors adverse effects
Platelet Function Tests
Prodrugs adverse effects
Prodrugs pharmacokinetics
Prodrugs therapeutic use
Purinergic P2Y Receptor Antagonists adverse effects
Purinergic P2Y Receptor Antagonists pharmacokinetics
Purinergic P2Y Receptor Antagonists therapeutic use
Receptors, Purinergic P2Y12 chemistry
Ticlopidine adverse effects
Ticlopidine pharmacokinetics
Ticlopidine therapeutic use
Blood Platelets drug effects
Drug Monitoring methods
Platelet Aggregation Inhibitors pharmacokinetics
Platelet Aggregation Inhibitors therapeutic use
Ticlopidine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1096-8652
- Volume :
- 86
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 21812020
- Full Text :
- https://doi.org/10.1002/ajh.22112