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Synthesis and anti-platelet activity of obovatol derivatives.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2011 Jul; Vol. 34 (7), pp. 1107-12. Date of Electronic Publication: 2011 Aug 03. - Publication Year :
- 2011
-
Abstract
- Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
- Subjects :
- Alcohols chemistry
Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Arachidonic Acid antagonists & inhibitors
Arachidonic Acid pharmacology
Biphenyl Compounds chemistry
Collagen pharmacology
Dose-Response Relationship, Drug
Phenyl Ethers chemistry
Platelet Aggregation Inhibitors chemical synthesis
Platelet Aggregation Inhibitors chemistry
Rabbits
Structure-Activity Relationship
Biphenyl Compounds pharmacology
Phenyl Ethers pharmacology
Platelet Activation drug effects
Platelet Aggregation drug effects
Platelet Aggregation Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1976-3786
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 21811917
- Full Text :
- https://doi.org/10.1007/s12272-011-0708-9