Back to Search
Start Over
Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted.
- Source :
-
Diabetes [Diabetes] 2011 Sep; Vol. 60 (9), pp. 2274-84. Date of Electronic Publication: 2011 Aug 01. - Publication Year :
- 2011
-
Abstract
- Objective: A prenatal hypoxic insult leading to intrauterine growth restriction (IUGR) increases the susceptibility to develop metabolic syndrome (MetS) later in life. Since resveratrol (Resv), the polyphenol produced by plants, exerts insulin-sensitizing effects, we tested whether Resv could prevent deleterious metabolic effects of being born IUGR.<br />Research Design and Methods: Pregnant rats were exposed to either a normoxic (control; 21% O(2)) or a hypoxic (IUGR; 11.5% O(2)) environment during the last third of gestation. After weaning, male offspring were randomly assigned to receive either a high-fat (HF; 45% fat) diet or an HF diet with Resv (4 g/kg diet) for 9 weeks when various parameters of the MetS were measured.<br />Results: Relative to normoxic controls, hypoxia-induced IUGR offspring developed a more severe MetS, including glucose intolerance and insulin resistance, increased intra-abdominal fat deposition and intra-abdominal adipocyte size, and increased plasma triacylglycerol (TG) and free fatty acids, as well as peripheral accumulation of TG, diacylglycerol, and ceramides. In only IUGR offspring, the administration of Resv reduced intra-abdominal fat deposition to levels comparable with controls, improved the plasma lipid profile, and reduced accumulation of TG and ceramides in the tissues. Moreover, Resv ameliorated insulin resistance and glucose intolerance as well as impaired Akt signaling in the liver and skeletal muscle of IUGR offspring and activated AMP-activated protein kinase, which likely contributed to improved metabolic parameters in Resv-treated IUGR rats.<br />Conclusions: Our results suggest that early, postnatal administration of Resv can improve the metabolic profile of HF-fed offspring born from pregnancies complicated by IUGR.
- Subjects :
- Animals
Body Weight physiology
Calorimetry, Indirect
Dietary Fats adverse effects
Dietary Fats metabolism
Energy Intake physiology
Female
Fetal Growth Retardation etiology
Hypoxia complications
Hypoxia metabolism
Insulin Resistance physiology
Male
Metabolic Syndrome etiology
Metabolic Syndrome metabolism
Motor Activity physiology
Pregnancy
Prenatal Exposure Delayed Effects metabolism
Rats
Resveratrol
Antioxidants pharmacology
Fetal Growth Retardation metabolism
Metabolic Syndrome prevention & control
Prenatal Exposure Delayed Effects prevention & control
Stilbenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1939-327X
- Volume :
- 60
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 21810598
- Full Text :
- https://doi.org/10.2337/db11-0374