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Outcome of ventilator-associated pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa treated with aerosolized colistin in neonates: a retrospective chart review.
- Source :
-
European journal of pediatrics [Eur J Pediatr] 2012 Feb; Vol. 171 (2), pp. 311-6. Date of Electronic Publication: 2011 Aug 02. - Publication Year :
- 2012
-
Abstract
- Multidrug-resistant (MDR) gram-negative bacteria-related nosocomial infections and ventilator-associated pneumonia (VAP) presents an emerging challenge to clinicians. Older antimicrobial agents such as colistin have become life-saving drugs because of the susceptibility of these pathogens. We report our experience with aerosolized colistin in two preterm and one term neonate with Acinetobacter baumannii and Pseudomonas aeruginosa-related VAP who were unresponsiveness to previous antimicrobial treatment. All pathogens were isolated from tracheal aspirate. We used 5 mg/kg (base activity) aerosolized colistin methanesulfonate sodium in every 12 h as an adjunctive therapy for VAP. VAP was treated by 14, 14, and 16-day courses of aerosolized colistin in these patients, respectively. No adverse effect such as nephrotoxicity or neurotoxicity was observed. We found that aerosolized colistin was tolerable and safe, and it may be an adjunctive treatment option for MDR gram-negative bacterial VAP in neonates. Further studies are needed to determine appropriate doses for aerosolized colistin and its eligibility as an alternative treatment choice in newborns.
- Subjects :
- Acinetobacter Infections microbiology
Administration, Inhalation
Anti-Bacterial Agents pharmacology
Colistin therapeutic use
Drug Administration Schedule
Drug Resistance, Multiple, Bacterial
Female
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases drug therapy
Infant, Premature, Diseases microbiology
Male
Pneumonia, Ventilator-Associated microbiology
Pseudomonas Infections microbiology
Retrospective Studies
Treatment Outcome
Acinetobacter Infections drug therapy
Acinetobacter baumannii drug effects
Acinetobacter baumannii isolation & purification
Anti-Bacterial Agents therapeutic use
Colistin analogs & derivatives
Pneumonia, Ventilator-Associated drug therapy
Pseudomonas Infections drug therapy
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1076
- Volume :
- 171
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 21809011
- Full Text :
- https://doi.org/10.1007/s00431-011-1537-z