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Curcumin derivatives as new ligands of Aβ peptides.
- Source :
-
Journal of biotechnology [J Biotechnol] 2011 Dec 20; Vol. 156 (4), pp. 317-24. Date of Electronic Publication: 2011 Jul 22. - Publication Year :
- 2011
-
Abstract
- Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Alzheimer Disease
Amyloid beta-Peptides chemistry
Amyloid beta-Peptides genetics
Animals
Brain Chemistry
Curcumin chemistry
Curcumin metabolism
Histocytochemistry
Humans
Mice
Mice, Transgenic
Molecular Dynamics Simulation
Nuclear Magnetic Resonance, Biomolecular
Peptide Fragments chemistry
Protein Binding
Solubility
Amyloid beta-Peptides metabolism
Curcumin analogs & derivatives
Peptide Fragments metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4863
- Volume :
- 156
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 21807037
- Full Text :
- https://doi.org/10.1016/j.jbiotec.2011.07.021