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Clinical significance of epidermal growth factor receptor mutations and insulin-like growth factor 1 and its binding protein 3 in advanced non-squamous non-small cell lung cancer.
- Source :
-
Oncology reports [Oncol Rep] 2011 Oct; Vol. 26 (4), pp. 795-803. Date of Electronic Publication: 2011 Jun 17. - Publication Year :
- 2011
-
Abstract
- This study of patients with advanced non-squamous non-small cell lung cancer (NSCLC) evaluated epidermal growth factor receptor (EGFR) mutation status and two serum markers, serum insulin-like growth factor 1 (IGF1) and IGF binding protein 3 (IGFBP3), for their associations to response to gefitinib therapy and for their prognostic impact. An immunoradiometric assay determined levels of IGF1 and IGFBP3 in serum from 68 patients with advanced non-squamous NSCLC. The peptic nucleic acid locked nucleic acid clamp method determined their EGFR somatic mutation status. We evaluated the relationship between each independent clinicopathological variable and the response to gefitinib therapy and the risk factors associated with prognosis. Having IGF1-positive serum as determined by the 75th percentile and having wild-type EGFR were both independent negative predictive factors for geftinib treatment by multivariate logistic regression model analysis. Both having serum positive for IGF1 as determined by the 25th percentile and having wild-type EGFR were significant independent negative prognostic factors for survival based on multivariate analysis. We demonstrated that having IGF1-positive serum predicts a negative response to gefitinib therapy independent of EGFR mutational status. We also demonstrated that both IGF1-positive serum and wild-type EGFR were independent poor prognostic factors in patients with non-squamous NSCLC who received gefitinib therapy.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor blood
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung pathology
Female
Gefitinib
Humans
Insulin-Like Growth Factor Binding Protein 3 genetics
Insulin-Like Growth Factor I genetics
Lung Neoplasms blood
Lung Neoplasms genetics
Lung Neoplasms pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Survival Rate
Treatment Outcome
Antineoplastic Agents therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
ErbB Receptors genetics
Insulin-Like Growth Factor Binding Protein 3 blood
Insulin-Like Growth Factor I metabolism
Lung Neoplasms drug therapy
Quinazolines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1791-2431
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 21805046
- Full Text :
- https://doi.org/10.3892/or.2011.1354