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Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats.
- Source :
-
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2011 Sep; Vol. 32 (9), pp. 1109-15. Date of Electronic Publication: 2011 Aug 01. - Publication Year :
- 2011
-
Abstract
- Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR).<br />Methods: The rats were administered amlodipine (1 mg·kg(-1)·d(-1)) alone, irbesartan (10 mg·kg(-1)·d(-1)) alone, or the combination of the two drugs for 4 months. The drugs were mixed into the rat chow. Blood pressure (BP) was continuously monitored in conscious animals. After the determination of BRS, the rats were killed for morphological evaluation of organ damages.<br />Results: The combination of low-dose irbesartan and amlodipine had statistically significant synergism on reduction of BP and BPV, amelioration of BRS and organ protection in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was associated with the decrease in systolic BPV (r=0.665, P<0.01); the decrease in aortic hypertrophy was associated with the increase in BRS (r=0.656, P<0.01); and the amelioration in renal lesion was associated with the increase in BRS (r=0.763, P<0.01) and the decrease in systolic BPV (r=0.706, P<0.01).<br />Conclusion: Long-term treatment with a combination of low-doses of amlodipine and irbesartan showed significant synergism on reduction of BP and BPV, restoration of BRS and organ protection in SHR. Besides BP reduction, the enhancement of BRS and reduction of BPV might contribute to the organ protection.
- Subjects :
- Amlodipine pharmacology
Animals
Antihypertensive Agents pharmacology
Baroreflex drug effects
Biphenyl Compounds pharmacology
Drug Synergism
Hypertension pathology
Hypertrophy, Left Ventricular drug therapy
Hypertrophy, Left Ventricular pathology
Irbesartan
Male
Rats
Rats, Inbred SHR
Tetrazoles pharmacology
Amlodipine therapeutic use
Antihypertensive Agents therapeutic use
Biphenyl Compounds therapeutic use
Blood Pressure drug effects
Hemodynamics drug effects
Hypertension drug therapy
Tetrazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1745-7254
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 21804575
- Full Text :
- https://doi.org/10.1038/aps.2011.88