Common variation at 10p12.31 near MLLT10 influences meningioma risk.

Authors :: Dobbins SE
Broderick P
Melin B
Feychting M
Johansen C
Andersson U
Brännström T
Schramm J
Olver B
Lloyd A
Ma YP
Hosking FJ
Lönn S
Ahlbom A
Henriksson R
Schoemaker MJ
Hepworth SJ
Hoffmann P
Mühleisen TW
Nöthen MM
Moebus S
Eisele L
Kosteljanetz M
Muir K
Swerdlow A
Simon M
Houlston RS
Source :: Nature genetics [Nat Genet] 2011 Jul 31; Vol. 43 (9), pp. 825-7. Date of Electronic Publication: 2011 Jul 31.
Publication Year :: 2011
Abstract: To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.<br />Competing Interests: Statement The authors declare no competing financial interests.