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Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro.
- Source :
-
Antiviral research [Antiviral Res] 2011 Sep; Vol. 91 (3), pp. 330-4. Date of Electronic Publication: 2011 Jul 21. - Publication Year :
- 2011
-
Abstract
- A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antiviral Agents pharmacology
Birds
Cells, Cultured
Cyclooxygenase 2 genetics
Cyclooxygenase 2 Inhibitors pharmacology
Dose-Response Relationship, Drug
Humans
Influenza A Virus, H1N1 Subtype drug effects
Influenza A Virus, H1N1 Subtype physiology
Influenza A Virus, H5N1 Subtype physiology
Influenza in Birds drug therapy
Influenza in Birds virology
Influenza, Human virology
Macrophages cytology
Macrophages virology
Reverse Transcriptase Polymerase Chain Reaction
Viral Proteins genetics
Virus Replication drug effects
Cyclooxygenase 2 metabolism
Influenza A Virus, H5N1 Subtype drug effects
Influenza, Human drug therapy
Macrophages drug effects
Signal Transduction drug effects
Sulfonamides pharmacology
Viral Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9096
- Volume :
- 91
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 21798291
- Full Text :
- https://doi.org/10.1016/j.antiviral.2011.07.011