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Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro.

Authors :
Lee SM
Gai WW
Cheung TK
Peiris JS
Source :
Antiviral research [Antiviral Res] 2011 Sep; Vol. 91 (3), pp. 330-4. Date of Electronic Publication: 2011 Jul 21.
Publication Year :
2011

Abstract

A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-9096
Volume :
91
Issue :
3
Database :
MEDLINE
Journal :
Antiviral research
Publication Type :
Academic Journal
Accession number :
21798291
Full Text :
https://doi.org/10.1016/j.antiviral.2011.07.011