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Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis.
- Source :
-
Journal of periodontal research [J Periodontal Res] 2011 Dec; Vol. 46 (6), pp. 749-55. Date of Electronic Publication: 2011 Jul 27. - Publication Year :
- 2011
-
Abstract
- Background and Objective: Oral microorganisms may be involved in the development of cardiovascular diseases, and Porphyromonas gingivalis is one of the periodontal microorganisms that has been found in carotid atheroma. The aim of this work was to study subgingival microorganisms and early carotid lesions in subjects with and without periodontitis.<br />Material and Methods: Eighty-eight subjects with periodontitis and 40 subjects without periodontitis underwent dental examinations in 2003. The presence of the periodontal microorganisms Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Tannerella forsythia was analyzed from subgingival plaque using PCR amplification. The common carotid artery was scanned using ultrasound and the calculated intima-media area (cIMA) was measured. The association between periodontitis, the cIMA value and the presence of periodontal microorganisms, together with several confounders, was studied in a multiple logistic regression model.<br />Results: Smoking [odds ratio (OR) = 5.64; p = 0.001), level of education (OR = 5.02; p < 0.05) and the presence of P. gingivalis (OR = 6.50; p < 0.05) were associated with periodontitis. Explanatory factors for the increased cIMA were periodontitis (OR = 4.22; p < 0.05), hypertension (OR = 4.81; p < 0.05), high body mass index (OR = 5.78; p < 0.01), male gender (OR = 3.30; p < 0.05) and poor socioeconomic status (OR = 4.34; p < 0.05). P. nigrescens (OR 4.08; p < 0.05) and P. gingivalis (OR 7.63; p < 0.01) also appeared as explanatory variables associated with increased cIMA values.<br />Conclusion: This cross-sectional study showed that P. nigrescens and P. gingivalis were significantly associated with increased cIMA values.<br /> (© 2011 John Wiley & Sons A/S.)
- Subjects :
- Atherosclerosis complications
Carotid Artery Diseases complications
Carotid Artery, Common diagnostic imaging
Carotid Artery, Common microbiology
Carotid Intima-Media Thickness
Carotid Stenosis microbiology
Case-Control Studies
Chi-Square Distribution
Cross-Sectional Studies
Female
Humans
Logistic Models
Male
Middle Aged
Risk Factors
Atherosclerosis microbiology
Carotid Artery Diseases microbiology
Periodontitis complications
Porphyromonas gingivalis isolation & purification
Prevotella nigrescens isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0765
- Volume :
- 46
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of periodontal research
- Publication Type :
- Academic Journal
- Accession number :
- 21793826
- Full Text :
- https://doi.org/10.1111/j.1600-0765.2011.01398.x