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Bacteria in the pathogenesis of inflammatory bowel disease.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2011 Aug; Vol. 39 (4), pp. 1067-72. - Publication Year :
- 2011
-
Abstract
- Twin studies have demonstrated the importance of environmental factors in the pathogenesis of inflammatory bowel disease, but progress has been relatively slow in identifying these, with the exception of smoking, which is positively associated with Crohn's disease and negatively associated with ulcerative colitis. Genetic studies have identified risk alleles which are involved in host-bacterial interactions and the mucosal barrier, and evidence is building for a likely pathogenic role for changes in the gut microbiome, with respect to both faecal and mucosa-associated microbiota. Some of these changes may be secondary to inflammation, nevertheless promising new therapeutic targets are beginning to emerge.
- Subjects :
- Animals
Epithelial Cells microbiology
Feces microbiology
Gastrointestinal Tract metabolism
Gastrointestinal Tract microbiology
Gastrointestinal Tract pathology
Humans
Immunity, Innate
Inflammatory Bowel Diseases drug therapy
Inflammatory Bowel Diseases immunology
Intestinal Mucosa metabolism
Intestinal Mucosa microbiology
Intestinal Mucosa pathology
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis complications
Inflammatory Bowel Diseases microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 21787349
- Full Text :
- https://doi.org/10.1042/BST0391067