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Computational design of a β-peptide that targets transmembrane helices.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2011 Aug 17; Vol. 133 (32), pp. 12378-81. Date of Electronic Publication: 2011 Jul 22. - Publication Year :
- 2011
-
Abstract
- The design of β-peptide foldamers targeting the transmembrane (TM) domains of complex natural membrane proteins has been a formidable challenge. A series of β-peptides was designed to stably insert in TM orientations in phospholipid bilayers. Their secondary structures and orientation in the phospholipid bilayer was characterized using biophysical methods. Computational methods were then devised to design a β-peptide that targeted a TM helix of the integrin α(IIb)β(3). The designed peptide (β-CHAMP) interacts with the isolated target TM domain of the protein and activates the intact integrin in vitro.
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 133
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 21780757
- Full Text :
- https://doi.org/10.1021/ja204215f