[Increasing efficacy of recanalization of infarction-associated coronary artery by means of pharmacological agent imitating pre- and postconditioning phenomenon (review of literature)].

Analyzing the literature data shows that the formation of the necrosis focus in patients presenting with acute myocardial infarction (AMI) is mainly completed within 2-4 hours from the moment of the development of coronary thrombosis. A positive effect of throm bolytic therapy and coronary angioplasty observed at later terms is apparently associated with restoration ofcoronaryperfusion in the periinfarction zone. The protecting effect of adenosine in acute myocardial infarction (AMI) does not probably depend upon the size of the infarction focus but is due to decreased incidence of the development of the no-reflow phenomenon. The protective effect on nicotinamide seen in patients with AMI is probably associated with improved coronary perfusion in the periinfarction zone. Opioids and cannabioids imitate the pre- and postconditioning phenomenon. Hence, these compounds after cl employed in comprehensive therapy ofAMI.