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Clinical significance of serum hepatocyte growth factor and epidermal growth factor gene somatic mutations in patients with non-squamous non-small cell lung cancer receiving gefitinib or erlotinib.
- Source :
-
Medical oncology (Northwood, London, England) [Med Oncol] 2012 Sep; Vol. 29 (3), pp. 1614-21. Date of Electronic Publication: 2011 Jul 21. - Publication Year :
- 2012
-
Abstract
- A study of patients with advanced non-squamous non-small cell lung cancer (NSCLC) evaluated epidermal growth factor receptor (EGFR) mutation status and serum hepatocyte growth factor (HGF) for their associations with response to gefitinib therapy and prognostic impact. An enzyme-linked immunosorbent assay was used to determine levels of HGF in serum from 96 Japanese patients with advanced non-squamous NSCLC. The peptic nucleic acid-locked nucleic acid clamp method was used to determine their EGFR somatic mutation status. We evaluated the relationship between each independent clinicopathological variable and the response to gefitinib therapy and risk factors associated with prognosis. HGF-positive serum status (hazard ratio, 1.536; 95% confidence interval, 1.042-2.400; P = 0.0295) had a significant and independent negative effect on progression-free survival among patients with wild-type EGFR. We demonstrate that having HGF-positive serum is predictive of a negative response to gefitinib therapy in patients with advanced NSCLC who harbor wild-type EGFR.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor analysis
Biomarkers, Tumor blood
Biomarkers, Tumor genetics
Disease-Free Survival
Enzyme-Linked Immunosorbent Assay
Erlotinib Hydrochloride
Female
Gefitinib
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mutation
Prognosis
Proportional Hazards Models
Quinazolines therapeutic use
Antineoplastic Agents therapeutic use
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung genetics
Epidermal Growth Factor genetics
Hepatocyte Growth Factor blood
Lung Neoplasms blood
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1559-131X
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Medical oncology (Northwood, London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21779929
- Full Text :
- https://doi.org/10.1007/s12032-011-0009-7