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[HPV-associated head and neck cancer. The basics of molecular and translational research].
- Source :
-
HNO [HNO] 2011 Sep; Vol. 59 (9), pp. 885-92. - Publication Year :
- 2011
-
Abstract
- Translational research refers to the interfaces between preclinical research and targeted short- and medium-term developments through to clinical standards. There are two distinct groups of oropharyngeal malignancies: those caused by tobacco and alcohol abuse and those caused by HPV infection. Although the prognosis of patients in the latter group is significantly better, this is not taken into consideration in the choice of treatment. However, less intensive use of radiotherapy, chemotherapy, or surgery, as well as targeted multimodal therapeutic approaches, is under research. This article summarizes the main events in the HPV life cycle, with emphasis on carcinogenic mechanisms and potential new molecular targets. Identifying distinct tumor entities of the oropharynx enables the design and development of new preventive and therapeutic strategies to reduce the incidence and mortality of HPV-associated oropharyngeal cancers in the near future.
- Subjects :
- Biomarkers, Tumor genetics
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Cell Transformation, Neoplastic genetics
Cell Transformation, Neoplastic pathology
Cyclin-Dependent Kinase Inhibitor p16 genetics
DNA, Viral genetics
ErbB Receptors genetics
Gene Expression Regulation, Neoplastic genetics
Human papillomavirus 16 genetics
Humans
Oropharyngeal Neoplasms genetics
Oropharyngeal Neoplasms virology
Otorhinolaryngologic Neoplasms pathology
Otorhinolaryngologic Neoplasms therapy
Papillomavirus Infections pathology
Papillomavirus Infections therapy
Prognosis
Signal Transduction genetics
Virus Latency genetics
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell virology
Otorhinolaryngologic Neoplasms genetics
Otorhinolaryngologic Neoplasms virology
Papillomavirus Infections genetics
Papillomavirus Infections virology
Translational Research, Biomedical
Subjects
Details
- Language :
- German
- ISSN :
- 1433-0458
- Volume :
- 59
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- HNO
- Publication Type :
- Academic Journal
- Accession number :
- 21769577
- Full Text :
- https://doi.org/10.1007/s00106-011-2357-1