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Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver.
- Source :
-
Molecular and cellular biochemistry [Mol Cell Biochem] 1990 Oct 15-Nov 8; Vol. 98 (1-2), pp. 177-82. - Publication Year :
- 1990
-
Abstract
- We have studied the effects of Efamol evening primrose oil (EPO) on fatty acid-binding proteins (L-FABP) of rat liver. EPO contains 72% cis-linoleic acid and 9% cis-gamma linolenic acid. EPO has been clinically used for treatment of a number of diseases in humans and animals. EPO is also known to lower cholesterol level in humans and animals. Feeding of an EPO supplemented diet to rats (n = 9) for 2 months decreases the oleate binding capacity of purified L-FABP of rat liver whereas the palmitate binding activity was increased by 38%. However, EPO feeding did not alter the L-FABP concentrations significantly as measured by using the fluorescence fatty acid probe, dansylamino undecanoic acid. Endogenous fatty acid analysis of L-FABPs revealed significant qualitative and quantitative changes in fatty acid pattern after EPO feeding. EPO feeding decreased the endogenous palmitate level by 53% and oleate level by 64% in L-FABPs and also EPO feeding decreased the total endogenous fatty acid content from 62 nanomole per mg of protein to 42 nanomole per mg of L-FABP (n = 3).
- Subjects :
- Animals
Cholesterol Esters metabolism
Eating
Fatty Acid-Binding Protein 7
Fatty Acid-Binding Proteins
Female
Humans
Hypolipidemic Agents pharmacology
Linoleic Acid
Liver drug effects
Oenothera biennis
Phospholipids metabolism
Plant Oils
Rats
Rats, Inbred Strains
Triglycerides metabolism
gamma-Linolenic Acid
Carrier Proteins metabolism
Fatty Acids, Essential pharmacology
Linoleic Acids pharmacology
Linolenic Acids pharmacology
Liver metabolism
Neoplasm Proteins
Nerve Tissue Proteins
Tumor Suppressor Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8177
- Volume :
- 98
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 2176271
- Full Text :
- https://doi.org/10.1007/BF00231382