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A quantitative assessment of alkaptonuria: testing the reliability of two disease severity scoring systems.
- Source :
-
Journal of inherited metabolic disease [J Inherit Metab Dis] 2011 Dec; Vol. 34 (6), pp. 1153-62. Date of Electronic Publication: 2011 Jul 09. - Publication Year :
- 2011
-
Abstract
- Alkaptonuria (AKU) is due to excessive homogentisic acid accumulation in body fluids due to lack of enzyme homogentisate dioxygenase leading in turn to varied clinical manifestations mainly by a process of conversion of HGA to a polymeric melanin-like pigment known as ochronosis. A potential treatment, a drug called nitisinone, to decrease formation of HGA is available. However, successful demonstration of its efficacy in modifying the natural history of AKU requires an effective quantitative assessment tool. We have described two potential tools that could be used to quantitate disease burden in AKU. One tool describes scoring the clinical features that includes clinical assessments, investigations and questionnaires in 15 patients with AKU. The second tool describes a scoring system that only includes items obtained from questionnaires used in 44 people with AKU. Statistical analyses were carried out on the two patient datasets to assess the AKU tools; these included the calculation of Chronbach's alpha, multidimensional scaling and simple linear regression analysis. The conclusion was that there was good evidence that the tools could be adopted as AKU assessment tools, but perhaps with further refinement before being used in the practical setting of a clinical trial.
- Subjects :
- Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Alkaptonuria drug therapy
Alkaptonuria enzymology
Causality
Cohort Studies
Comorbidity
Cyclohexanones therapeutic use
Female
Homogentisate 1,2-Dioxygenase deficiency
Humans
Hypertension epidemiology
Male
Middle Aged
Nitrobenzoates therapeutic use
Ochronosis drug therapy
Ochronosis enzymology
Pain epidemiology
Regression Analysis
Reproducibility of Results
Sex Distribution
Smoking epidemiology
Surveys and Questionnaires
Alkaptonuria diagnosis
Alkaptonuria epidemiology
Homogentisic Acid metabolism
Ochronosis diagnosis
Ochronosis epidemiology
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2665
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of inherited metabolic disease
- Publication Type :
- Academic Journal
- Accession number :
- 21744089
- Full Text :
- https://doi.org/10.1007/s10545-011-9367-8