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[The physiological mechanisms of the antihypoxic action of the liposomes].

Authors :
Pozharov VP
Miniaĭlenko TD
Stefanov AV
Bryginskiĭ SA
Seredenko MM
Lishko VK
Source :
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova [Fiziol Zh SSSR Im I M Sechenova] 1990 Jul; Vol. 76 (7), pp. 897-902.
Publication Year :
1990

Abstract

The effect of phospholipids introduced into the vascular bed in the form of liposomes, was studied in pats in conditions of breathing with hypoxic gas mixture containing 7% of oxygen in nitrogen. The liposomes were shown to improve the oxygen diffusion from the blood into tissues and from air to the blood. In the result of this, the degree of the tissue hypoxia is considerably reduced, the process of peroxide oxidation of lipids is inhibited, and the efficacy of external respiration and gas exchange is increased.

Details

Language :
Russian
ISSN :
0015-329X
Volume :
76
Issue :
7
Database :
MEDLINE
Journal :
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova
Publication Type :
Academic Journal
Accession number :
2174384