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[The physiological mechanisms of the antihypoxic action of the liposomes].
- Source :
-
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova [Fiziol Zh SSSR Im I M Sechenova] 1990 Jul; Vol. 76 (7), pp. 897-902. - Publication Year :
- 1990
-
Abstract
- The effect of phospholipids introduced into the vascular bed in the form of liposomes, was studied in pats in conditions of breathing with hypoxic gas mixture containing 7% of oxygen in nitrogen. The liposomes were shown to improve the oxygen diffusion from the blood into tissues and from air to the blood. In the result of this, the degree of the tissue hypoxia is considerably reduced, the process of peroxide oxidation of lipids is inhibited, and the efficacy of external respiration and gas exchange is increased.
- Subjects :
- Animals
Carbon Dioxide blood
Drug Carriers
Drug Evaluation, Preclinical
Hydrogen-Ion Concentration
Hypoxia blood
Hypoxia drug therapy
Hypoxia etiology
Liposomes
Nitrogen administration & dosage
Oxygen administration & dosage
Oxygen blood
Partial Pressure
Phospholipids physiology
Rats
Rats, Inbred Strains
Hypoxia physiopathology
Phospholipids administration & dosage
Subjects
Details
- Language :
- Russian
- ISSN :
- 0015-329X
- Volume :
- 76
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova
- Publication Type :
- Academic Journal
- Accession number :
- 2174384